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1

Structure−Activity Relationships of Antitubercular Nitroimidazoles. 1. Structural Features Associated with Aerobic and Anaerobic Activities of 4- and 5-Nitroimidazoles

Kim, Pilho, Zhang, Liang, Manjunatha, Ujjini H., Singh, Ramandeep, Patel, Sejal, Jiricek, Jan, Keller, Thomas H., Boshoff, Helena I., Barry, Clifton E., Dowd, Cynthia S.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 275 KB

english, 2009

2

Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment

Ibekwe, Nneka N., Nvau, John B., Oladosu, Peters O., Usman, Auwal M., Ibrahim, Kolo, Boshoff, Helena I., Dowd, Cynthia S., Orisadipe, Abayomi T., Aiyelaagbe, Olapeju, Adesomoju, Akinbo A., Barry, Clif

Journal:

Journal of Ethnopharmacology

Year:

2014

Language:

english

File:

PDF, 882 KB

english, 2014

3

The mechanism of action of PA-824

Manjunatha, Ujjini, Boshoff, Helena I.M., Barry, Clifton E.

Journal:

Communicative & Integrative Biology

Year:

2009

Language:

english

File:

PDF, 1.22 MB

english, 2009

4

The present state of the tuberculosis drug development pipeline

J Libardo, M Daben, Boshoff, Helena IM, Barry, Clifton E

Journal:

Current Opinion in Pharmacology

Year:

2018

Language:

english

File:

PDF, 2.08 MB

english, 2018

5

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

Dong, Yin Yao, Wang, Hua, Pike, Ashley C.W., Cochrane, Stephen A., Hamedzadeh, Sadra, Wyszyński, Filip J., Bushell, Simon R., Royer, Sylvain F., Widdick, David A., Sajid, Andaleeb, Boshoff, Helena I.,

Journal:

Year:

2018

Language:

english

File:

PDF, 8.70 MB

english, 2018

6

Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode

Whitehouse, Andrew J, Libardo, M. Daben J., Kasbekar, Monica, Brear, Paul D, Fischer, Gerhard, Thomas, Craig J, Barry, Cliff, Boshoff, Helena I. M., Coyne, Anthony G, Abell, Chris

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 2.89 MB

english, 2019

7

Design, Synthesis, Biological Evaluation and Molecular Dynamic Simulation Studies of Diphenyl Ether Derivatives as Antitubercular and Antibacterial Agents

Khade, Amol B., Eshwara, Vandana K., Boshoff, Helena I.M., Arora, Kriti, Tiwari, Ashutosh, Bhat, Pritesh, Tiwari, Mradul, Shenoy, G. Gautham

Journal:

ChemistrySelect

Year:

2020

Language:

english

File:

PDF, 2.06 MB

english, 2020

8

PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis

Wang, Qinglan, Boshoff, Helena I. M., Harrison, Justin R., Ray, Peter C., Green, Simon R., Wyatt, Paul G., Barry, Clifton E.

Journal:

Year:

2020

File:

PDF, 714 KB

2020

9

ChemInform Abstract: The Effect of 5-Substitution on the Electrochemical Behavior and Antitubercular Activity of PA-824.

Soledad Bollo, Luis J. Nunez-Vergara, Sunhee Kang, Liang Zhang, Helena I. Boshoff, Clifton E. III Barry, Juan A. Squella, Cynthia S. Dowd

Journal:

Year:

2011

Language:

english

File:

PDF, 27 KB

english, 2011

10

The effect of 5-substitution on the electrochemical behavior and antitubercular activity of PA-824

Soledad Bollo, Luis J. Núñez-Vergara, Sunhee Kang, Liang Zhang, Helena I. Boshoff, Clifton E. Barry III, Juan A. Squella, Cynthia S. Dowd

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 687 KB

english, 2011

11

The impact of genomics on discovering drugs against infectious diseases

Helena I.M. Boshoff, Ujjini H. Manjunatha

Journal:

Microbes and Infection

Year:

2006

Language:

english

File:

PDF, 245 KB

english, 2006

12

Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities

Anna C. Giddens, Lone Nielsen, Helena I. Boshoff, Deniz Tasdemir, Remo Perozzo, Marcel Kaiser, Feng Wang, James C. Sacchettini, Brent R. Copp

Journal:

Year:

2008

Language:

english

File:

PDF, 274 KB

english, 2008

13

Antimycobacterial natural products: synthesis and preliminary biological evaluation of the oxazole-containing alkaloid texaline

Anna C. Giddens, Helena I.M. Boshoff, Scott G. Franzblau, Clifton E. Barry III, Brent R. Copp

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 105 KB

english, 2005

14

Top down characterization of secreted proteins fromMycobacterium tuberculosisby electron capture dissociation mass spectrometry

Ying Ge, Mariam ElNaggar, Siu Kwan Sze, Han Bin Oh, Tadhg P Begley, Fred W McLafferty, Helena Boshoff, Clifton E Barry III

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2003

Language:

english

File:

PDF, 668 KB

english, 2003

15

Quantification of small molecule organic acids from Mycobacterium tuberculosis culture supernatant using ion exclusion liquid chromatography/mass spectrometry

Michael B. Goodwin, Helena I. Boshoff, Clifton E. Barry 3rd, Cynthia S. Dowd

Journal:

Rapid Communications in Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 227 KB

english, 2006

16

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

Meera Gurumurthy, Tathagata Mukherjee, Cynthia S. Dowd, Ramandeep Singh, Pornwaratt Niyomrattanakit, Jo Ann Tay, Amit Nayyar, Yong Sok Lee, Joseph Cherian, Helena I. Boshoff, Thomas Dick, Clifton E. B

Journal:

Year:

2012

Language:

english

File:

PDF, 957 KB

english, 2012

17

Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis

Backus, Keriann M, Boshoff, Helena I, Barry, Conor S, Boutureira, Omar, Patel, Mitul K, D'Hooge, François, Lee, Seung Seo, Via, Laura E, Tahlan, Kapil, Barry, Clifton E

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 973 KB

english, 2011

18

Getting the iron out

Barry, Clifton E., Boshoff, Helena

Journal:

Nature Chemical Biology

Year:

2005

Language:

english

File:

PDF, 126 KB

english, 2005

19

Tuberculosis — metabolism and respiration in the absence of growth

Boshoff, Helena I. M., Barry, Clifton E.

Journal:

Nature Reviews Microbiology

Year:

2005

Language:

english

File:

PDF, 319 KB

english, 2005

20

Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes: author's reply

Barry, Clifton E., Boshoff, Helena I., Dartois, Véronique, Dick, Thomas, Ehrt, Sabine, Flynn, JoAnne, Schnappinger, Dirk, Wilkinson, Robert J., Young, Douglas

Journal:

Nature Reviews Microbiology

Year:

2010

Language:

english

File:

PDF, 129 KB

english, 2010

21

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

Barry, Clifton E., Boshoff, Helena I., Dartois, Véronique, Dick, Thomas, Ehrt, Sabine, Flynn, JoAnne, Schnappinger, Dirk, Wilkinson, Robert J., Young, Douglas

Journal:

Nature Reviews Microbiology

Year:

2009

Language:

english

File:

PDF, 870 KB

english, 2009

22

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

Moraski, Garrett C., Markley, Lowell D., Hipskind, Philip A., Boshoff, Helena, Cho, Sanghyun, Franzblau, Scott G., Miller, Marvin J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 971 KB

english, 2011

23

Development of a Selective Activity-Based Probe for Adenylating Enzymes: Profiling MbtA Involved in Siderophore Biosynthesis from Mycobacterium tuberculosis

Duckworth, Benjamin P., Wilson, Daniel J., Nelson, Kathryn M., Boshoff, Helena I., Barry, Clifton E., Aldrich, Courtney C.

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 2.39 MB

english, 2012

24

C4-Alkylthiols with activity against Moraxella catarrhalis and Mycobacterium tuberculosis

Maya B. Kostova, Carey J. Myers, Tim N. Beck, Balbina J. Plotkin, Jacalyn M. Green, Helena I.M. Boshoff, Clifton E. Barry III, Jeffrey R. Deschamps, Monika I. Konaklieva

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 683 KB

english, 2011

25

Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers

Stephen T. McCracken, Marcel Kaiser, Helena I. Boshoff, Peter D.W. Boyd, Brent R. Copp

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.51 MB

english, 2012

26

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

Garrett C. Moraski, Lowell D. Markley, Mayland Chang, Sanghyun Cho, Scott G. Franzblau, Chang Hwa Hwang, Helena Boshoff, Marvin J. Miller

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 584 KB

english, 2012

27

Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs

Eugene Uh, Emily R. Jackson, Géraldine San Jose, Marcus Maddox, Robin E. Lee, Richard E. Lee, Helena I. Boshoff, Cynthia S. Dowd

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 508 KB

english, 2011

28

Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosis

Benjamin P. Duckworth, Todd W. Geders, Divya Tiwari, Helena I. Boshoff, Paul A. Sibbald, Clifton E. Barry III, Dirk Schnappinger, Barry C. Finzel, Courtney C. Aldrich

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 519 KB

english, 2011

29

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

Susan E. Cellitti, Jennifer Shaffer, David H. Jones, Tathagata Mukherjee, Meera Gurumurthy, Badry Bursulaya, Helena I. Boshoff, Inhee Choi, Amit Nayyar, Yong Sok Lee, Joseph Cherian, Pornwaratt Niyomr

Journal:

Year:

2012

Language:

english

File:

PDF, 1.50 MB

english, 2012

30

The Mycobacterium tuberculosis β-oxidation genes echA5 and fadB3 are dispensable for growth in vitro and in vivo

Kerstin J. Williams, Helena I. Boshoff, Nitya Krishnan, Jacqueline Gonzales, Dirk Schnappinger, Brian D. Robertson

Journal:

Year:

2011

Language:

english

File:

PDF, 776 KB

english, 2011

31

Structure–Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-Nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-Amino PA-824).

Cherian, Joseph, Choi, Inhee, Nayyar, Amit, Manjunatha, Ujjini H., Mukherjee, Tathagata, Lee, Yong Sok, Boshoff, Helena I., Singh, Ramandeep, Ha, Young Hwan, Goodwin, Michael

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.33 MB

english, 2011

32

Nitroimidazoles for the treatment of TB: past, present and future

Mukherjee, Tathagata, Boshoff, Helena

Journal:

Future Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.94 MB

english, 2011

33

DnaE2 Polymerase Contributes to In Vivo Survival and the Emergence of Drug Resistance in Mycobacterium tuberculosis

Helena I.M. Boshoff, Michael B. Reed, Clifton E. Barry III, Valerie Mizrahi

Journal:

Year:

2003

Language:

english

File:

PDF, 133 KB

english, 2003

34

Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis

Pradeep Kumar, Kriti Arora, John R. Lloyd, Ill Y. Lee, Vinod Nair, Elizabeth Fischer, Helena I. M. Boshoff, Clifton E. Barry III

Journal:

Molecular Microbiology

Year:

2012

Language:

english

File:

PDF, 973 KB

english, 2012

35

5‘- O -[( N -Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins

Qiao, Chunhua, Gupte, Amol, Boshoff, Helena I., Wilson, Daniel J., Bennett, Eric M., Somu, Ravindranadh V., Barry, Clifton E., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 350 KB

english, 2007

36

Pathway-Selective Sensitization of Mycobacterium tuberculosis for Target-Based Whole-Cell Screening

Garth L. Abrahams, Anuradha Kumar, Suzana Savvi, Alvin W. Hung, Shijun Wen, Chris Abell, Clifton E. Barry III, David R. Sherman, Helena I.M. Boshoff, Valerie Mizrahi

Journal:

Chemistry & Biology

Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

37

Structure–activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling

Ill-Young Lee, Todd D. Gruber, Amanda Samuels, Minhan Yun, Bora Nam, Minseo Kang, Kathryn Crowley, Benjamin Winterroth, Helena I. Boshoff, Clifton E. Barry III

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 633 KB

english, 2013

38

Is the mycobacterial cell wall a hopeless drug target for latent tuberculosis?

Helena I. Boshoff, Clifton E. Barry III

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2006

Language:

english

File:

PDF, 269 KB

english, 2006

39

Mechanisms underlying mycobacterial infections

Helena I Boshoff, Kapil Tahlan

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2010

Language:

english

File:

PDF, 80 KB

english, 2010

40

Systems biology approaches to understanding mycobacterial survival mechanisms

Helena I.M. Boshoff, Desmond S. Lun

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2010

Language:

english

File:

PDF, 225 KB

english, 2010

41

Bioactive Pyridine- N -oxide Disulfides from Allium stipitatum ¶

O’Donnell, Gemma, Poeschl, Rosemarie, Zimhony, Oren, Gunaratnam, Mekala, Moreira, Joao B. C., Neidle, Stephen, Evangelopoulos, Dimitrios, Bhakta, Sanjib, Malkinson, John P., Boshoff, Helena I., Lenaer

Journal:

Journal of Natural Products

Year:

2009

Language:

english

File:

PDF, 242 KB

english, 2009

42

Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′- O -[ N -(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosis

Gupte, Amol, Boshoff, Helena I., Wilson, Daniel J., Neres, João, Labello, Nicholas P., Somu, Ravindranadh V., Xing, Chengguo, Barry, Clifton E., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.44 MB

english, 2008

43

Advancement of Imidazo[1,2- a ]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis

Moraski, Garrett C., Markley, Lowell D., Cramer, Jeffrey, Hipskind, Philip A., Boshoff, Helena, Bailey, Mai A., Alling, Torey, Ollinger, Juliane, Parish, Tanya, Miller, Marvin J.

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 349 KB

english, 2013

44

[Progress in Drug Research] Systems Biological Approaches in Infectious Diseases Volume 64 || Metabolic control analysis to identify optimal drug targets

Boshoff, Helena I., Barry, Clifton E.

Year:

2007

Language:

english

File:

PDF, 200 KB

english, 2007

45

A novel F 420 -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents

Gurumurthy, Meera, Rao, Martin, Mukherjee, Tathagata, Rao, Srinivasa P. S., Boshoff, Helena I., Dick, Thomas, Barry, Clifton E., Manjunatha, Ujjini H.

Journal:

Molecular Microbiology

Year:

2013

Language:

english

File:

PDF, 924 KB

english, 2013

46

Non-Nucleoside Inhibitors of BasE, an Adenylating Enzyme in the Siderophore Biosynthetic Pathway of the Opportunistic Pathogen Acinetobacter baumannii

Neres, João, Engelhart, Curtis A., Drake, Eric J., Wilson, Daniel J., Fu, Peng, Boshoff, Helena I., Barry, Clifton E., Gulick, Andrew M., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.12 MB

english, 2013

47

Rationally Designed Nucleoside Antibiotics That Inhibit Siderophore Biosynthesis of Mycobacterium t uberculosis

Somu, Ravindranadh V., Boshoff, Helena, Qiao, Chunhua, Bennett, Eric M., Barry, Clifton E., Aldrich, Courtney C.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 118 KB

english, 2006

48

[Progress in Drug Research] Systems Biological Approaches in Infectious Diseases Volume 64 || Toward whole cell modeling and simulation: Comprehensive functional genomics through the constraint-based approach

Boshoff, Helena I., Barry, Clifton E.

Year:

2007

Language:

english

File:

PDF, 871 KB

english, 2007

49

Structure–activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis

Meissner, Anja, Boshoff, Helena I., Vasan, Mahalakshmi, Duckworth, Benjamin P., Barry, Clifton E., Aldrich, Courtney C.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 756 KB

english, 2013

50

Design, Synthesis, and Biological Evaluation of β-Ketosulfonamide Adenylation Inhibitors as Potential Antitubercular Agents

Vannada, Jagadeshwar, Bennett, Eric M., Wilson, Daniel J., Boshoff, Helena I., Barry, Clifton E., Aldrich, Courtney C.

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 98 KB

english, 2006

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